Researchers at Indian Nagaland University have discovered a naturally occurring plant compound, Sinapic acid, that significantly accelerates wound healing in diabetic conditions. This is reported by ANI, a partner of TV BRICS.

The breakthrough offers a promising step towards developing safe, affordable, and natural treatments for one of diabetes’ most persistent complications – delayed wound recovery.

This is the first global study to demonstrate that Sinapic acid, when taken orally, enhances diabetic wound healing in preclinical models. The compound works by activating the SIRT1 pathway, a key mechanism responsible for tissue regeneration, blood vessel formation, and inflammation control.

The multidisciplinary project brought together scientists specialising in biotechnology, pharmacology, biochemistry, and medical sciences.

Exploring a plant-based alternative, the researchers found that Sinapic acid stimulates tissue repair, reduces inflammation, and promotes angiogenesis. Interestingly, a lower dose (20 mg/kg) proved more effective than a higher one, a finding known as an “inverted dose-response” pattern, which may influence future clinical applications.

The discovery could have a transformative impact on diabetic wound management by reducing amputation risks and providing a cost-effective therapy for patients in rural regions.

Future research will focus on advancing this innovation through molecular pathway analysis, safety and toxicity studies, formulation development, and pilot clinical trials in diabetic patients to confirm efficacy and safety.

TVBRICS